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LayN-Elastin
-. Elatin is a major extracellular matrix proteins with collagen
-. Elastin is highly elastic protein in connective tissues and allows many tissues in the body including skin to resume their shape
-. The lysine residues of cross-linking domain are deaminated by lysyl oxidase and conform stable elastin polymer
Functions ● Major extracellular matrix (ECM) protein in tissues ● Formation of elastin fibers in skin dermis and repair or fill worn out elastin fibers ● LayN-Elastin will be delivered to skin dermis. Elastin fibers are present in dermis
LayN-SOD
-. LayN-SOD is a recombinant protein combining LayN-Pep and Human SOD1 (Superoxide Dismutase 1)
-. SOD is an enzymatic anti-oxidant protein naturally present in the human body
-. Protecting the skin from external stresses and photo-aging
-. LayN-Pep effectively deliver SOD protein to inner skin layers
Functions ● Anti-Oxidant Neutralizing the superoxide free radicals (Source: Dermatoendocrinol. 2012 1;4(3):232-235) ● Skin Protection during RT (Radiation Therapy) Scavenger for ROS and free radicals (Source: Drug Discov. Ther. 2012;6(4):169-177) ● Anti-Inflammation Inhibition of UV-induced skin inflammation (Source: Exp. Dermatol. 1997;6(3):116-121) ● Inhibition of Skin Fibrosis Exchange myofibroblasts into fibroblasts (Source: Free Radic. Biol. Med. 2001 1;30(1):30-42)
LayN-BROM
-. LayN-BROM is a recombinant protein combining LayN-Pep and Bromelain (Ananas comosus (Pineapple), Stem)
-. Bromelain is a main peptidase in pineapple stem extracts
-. Pineapple extracts containing bromelain have a long traditional medicine among the natives of south and central america for wound healing, burn and anti-swelling/bruising
Functions ● Anti-Inflammation (Source: Evid. Based Complement Alternat. Med. 2004;1(3):251-257) ● Anti-Swelling/Bruising (Source: J. Obstet. Gynaecol. Br. Commonw. 1972;79(10):951-953) ● Anti-Tumor (Sources: Cancer Lett. 2010 28;290(2):148-156, Planta Med. 2007;73(13):1377-1383) ● Wound Healing (Source: J. Surg. Res. 2012;176(2):503-509)
LayN-TB4X
-. LayN-TB4X is a recombinant protein combining LayN-Pep and Human TB4X (Thymosin beta-4)
-. TB4X is a actin sequestering protein which plays a role in regulation of actin polymerization in almost human cells
-. TB4X is involved in cell proliferation, differentiation and migration
Functions ● Wound Healing Angiogenesis by endothelial cell differentiation & migration Stimulate collagen synthesis & deposition (Source: J. Invest. Dermatol. 1999;113(3):364-368) ● Hair Growth Hair follicles stem cell growth, differentiation & migration (Sources: Ann. N Y Acad. Sci. 2007;1112:95-103, FASEB J. 2004;18(2):385-387)
LayN-TRX
-. LayN-TRX is a recombinant protein combining LayN-Pep and Human TRX (Thioredoxin)
-. TRX is a small protein that act as a antioxidant ubiquitously present in human body
-. TRX is modulate cellular red-ox signals and maintain cellular oxidation state
Functions ● Anti-Oxidant Maintain cellular oxidation state by transduction of red-ox signals (Source: Proc. Natl. Acad. Sci. 1999 30;96(7):4131-4136) ● Anti-Inflammation (Source: Ann. N Y Acad. Sci. 2005;1055:1-12)
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